Narcolepsy – an Overview

What is Narcolepsy?

Narcolepsy is a long-term brain disorder which makes a person unable to regulate a sleep-wake cycles. In a simple terms, a person would fall asleep suddenly at unsuitable times. Due to this, the brain would become unable to access the sleeping and waking up patterns of a person.

Narcolepsy is a sleep disorder characterized by the followings,

  1. Extreme daytime sleepiness
  2. Sleep attacks
  3. Sleep paralysis
  4. Hallucinations and
  5. Cataplexy

Narcolepsy is a rare sleeping disorder. It occurs to people about 1 in 2,000 to 3,000. No gender difference is seen for the causes of narcolepsy, it affects both men and women on equal terms. However, the narcolepsy symptoms are mostly develops in childhood or to the teens. The diagnosis of narcolepsy might take years or sometimes decades once the symptoms of narcolepsy is developed on a person.

Genetic issues might causes narcolepsy. Family members of the patients are at a higher risk of developing a this sleeping disorder, narcolepsy. Nevertheless, developing narcolepsy is a complex process of genes and is a provocative action; Therefore, many family members of a person affected with narcolepsy may not expose to it.

What are the causes of Narcolepsy?

Narcolepsy is one of the major sleeping problem when it occurs to a person. The suffering from a sleeping disorder is huge and thus not everyone will be able to tackle and get over with such health condition. However, narcolepsy occurs rarely to people but most of the people who experiences such symptoms of narcolepsy wonders about what causes narcolepsy? Well, the causes of narcolepsy varies from a person to person such as excessive sleeping conditions, sleep paralysis or attacks and cataplexy.

The major problem occurs by narcolepsy with cataplexy. This is caused by the reduction of Orexin (Hypocretin) chemical in the brain. Hypocretin is one of the important chemical present in the brain which works in regulation of wakefulness and rapid eye movement (REM) sleep. The loss of Orexin in the brain causes a person to feel difficult to stay awake for a long time. However, from the research papers that has been submitted so far gave an another cause for narcolepsy is that genetic predisposition. A person born with containing certain might have the higher risk for developing narcolepsy. Children and teens are the ones who gets affected by this sleeping disorder often, that results in lack of concentration in education and competing in exams and other activities.

The causes of narcolepsy in children is due to the lack of immune power in them. When a infection affects the immune system of a child, rather simply attacking the system, if becomes confused and start to attack some of the specialized cells in the brain that are responsible for producing hypocretin and as a result leads to the symptoms of narcolepsy. Since, this issue is occurred due to the lack of healthy cells by the immune system and thus it makes narcolepsy as an autoimmune disease by which the immune system in your body starts to attack the healthy cells too. One of the triggering events of narcolepsy to a person is H1N1 (Swine Flu) influenza virus.

What are the types of Narcolepsy?

The symptoms of narcolepsy generally varies from a person to person, some might feel for a temporary effect and to others it would have become severe. Other than the characterization of narcolepsy that has been mentioned previously, there are two types of narcolepsy that affects the people, namely;

1. Narcolepsy with Cataplexy – There are many narcolepsy symptoms available and the one that affects deeply is narcolepsy with cataplexy. A person would experience a sudden weakness in the muscle and physical collapse that almost makes a person to lose control over the muscles in the face, arms, legs, or torso. The side effects of narcolepsy with cataplexy includes slurred speech, sagging jaw, potential collapse, and paralysis (unable to move or speak). Cataplexy is usually triggered by the strong emotion, such as anger or laughter.

2. Narcolepsy without Cataplexy– A person affected with the narcolepsy without cataplexy has all the existing symptoms of narcolepsy such as extreme sleepiness, sleep attacks, hallucinations, and paralysis. However, the effects of the issue does not encounter any of the sudden muscles weakness such as narcolepsy with cataplexy encounters due the triggering by certain strong emotions and it is also less severe and can be treated easily with the proper medication.

What is Cataplexy?

Cataplexy is a medical condition that causes a sudden or unexpected weakness in the muscle that is triggered by emotions such as excitement, sadness or anger. The attack of the disorder might lasts for few seconds to a couple of minutes that results in jaw dropping, weakness in the neck and buckling of the knees. Approximately 70% of the people who are suffering from narcolepsy are likely to experience cataplexy which is caused by the autoimmune disease that destroys the neurons which are responsible for the production of neuropeptides hypocretin (Orexin) that works in regulating the wakefulness to a person. There are no reports on the occurrence of cataplexy without narcolepsy in people.

Symptoms of Narcolepsy

The most noticeable narcolepsy symptoms are extreme daytime sleepiness and cataplexy. The first symptom that is often developed in a person is excessive sleepiness in daytime by which many people are have been suffering with for years before they receive a proper diagnosis and treatment for this sleeping disorder. Some of the common symptoms of narcolepsy is mentioned in the following;

  • Excessive Sleepiness– A person will feel drowsy throughout the day, and have some difficulty in concentrating on the work and staying awake.
  • Sleep Attacks– A person would suddenly fall asleep in the middle of work without any warning.
  • Sleep Paralysis– It is a temporary inability of a person to move or speak or do any actions when waking up or falling asleep. The brain cycle acts as paralyzed state between the sleeping or waking terms.
  • Hallucinations– There are two types of hallucinations that would cause to the patients,
  1. Hypnogogic HallucinationsOccurrence of dreams that comes often once you have fall asleep.
  2. Hypnopompic Hallucinations– Occurrence of dreams at the time of before or during waking up from sleep.
  • Cataplexy– A medical condition that occurs due to the sudden episode of muscle control and weakness and physical collapse that is caused to a person due to strong emotions such as laughter and anger.

If you witness any of the above mentioned symptoms then it is really important to take a consult with your doctor or a sleep specialist who would provide you with the proper narcolepsy treatments that may help greatly in improving your health conditions.

Treatment for Narcolepsy

The treatment for narcolepsy are highly available in the medical field.  There are numerous treatments that one could get to treat the sleeping disorder. However, not all of the available medications are very much an effective therapy for narcolepsy. Of which some drugs would help you slowly in treating the disorder or will not have sufficient effect on it, however, we here at Narcolepsy Study, provides the information about the most reliable and very effective drugs in treating narcolepsy.

  1. Modafinil
  2. Adderall
  3. Provigil

Modafinil

Adderall
Ingredient Modafinil

Amphetamine and Dextroamphetamine

Medical Uses

Narcolepsy, Obstructive sleep apnea, shift work sleep disorder ADHD and Narcolepsy

Formulation

Tablet

Immediate-release or Extended-release

Dosages

100mg and 200mg

5mg, 10mg, 15mg, 20mg, 25mg and 30mg.
Legal Status Schedule IV (US)

Schedule II (US)

Manufacturer

Cephalon Inc.

Shire Pharmaceuticals

Half-Life

12 hours

11-13 hours

Duration of Effect

6 to 8 hours

4 to 6 hours

FDA Approval

1998

1996

Common Side Effects

Dizziness, Headache, Insomnia, Nausea, and  Nervousness.

Abdominal pain, Dizziness, Dry Mouth, Headache, Insomnia, Nausea, and Weight loss.

Studies Say Adderall And Modafinil Are The Best Remedies For Narcolepsy

Modafinil and Adderall

Take Adderall and Modafinil for narcolepsy, a sleep disorder by which an individual suffers from excessive sleepiness, sleep paralysis and hallucinations. A recent study says, ADHD medications are the best remedy for a person with narcolepsy, and with optimum treatment, most of the people would experience great effectiveness and other related sleep disorders are brought under the control. Use Modafinil and Adderall which produce great benefits with some of your medical problems. These medicines will make you stay awake especially at biting times such as at work or operating a heavy machine or at school or when driving a vehicle.

Our experts at narcolepsystudy.com say Adderall and Modafinil Narcolepsy medicine will cause lesser side effects compared to other medications after they have well researched. Take Adderall for narcolepsy as this pill works by affecting the chemicals in the brain of people with narcolepsy and makes them stay asleep. Like Adderall, Modafinil also follows the same working process in treating for  narcolepsy. Before choosing the pill for your hypersomnia disorder, consult your physician which is one is right for your health condition.

How Modafinil and Adderall for narcolepsy considered as the most efficient?

Both the medications are used in the treatment of narcolepsy and produce a sense of asleep in the user. Both are also utilized for ADHD and another condition of cognitive impairments since Adderall medicine has been approved by the Department of Food and Drugs Administration for this purpose while Modafinil medication prescribed off-label by many psychiatrists. Moreover, these two pills have same effects, attributes, but noticed some distinctive variation between them. Both Adderall and Modafinil medicines work on the Norepinephrine, Dopamine, and Serotonin neurotransmitters to create a psycho-stimulation state. The working mechanism of both these medicines considered to be effective for excessive sleepiness disorder.

Modafinil

Modafinil is a medication used for the treatment of anti-anxiety hyperactive disorder and narcolepsy. This medicine is also called as a nootropic and act as a smart drug. It increases the function of cognitive skills in different ways. There are numerous smart medications available, but this medicine is considered to be the best smart drug for these reasons

Modafinil – Narcolepsy Study shows that this medication is the most potentModafinil

Of the majority of the medications utilized to treat narcolepsy all through time, Modafinil and its unadulterated detach forms, Armodafinil, have ended up being the best effective form of narcolepsy pill by far. Studies have demonstrated that patients taking Modafinil encounter as much as 50% improvement in controlling excessive daylight sleepiness, a 25% change in lessening sleep-related rates, and an extraordinary change in sleep quality also.

For effortlessness and to stay away from redundancy, whatever is left of this guide will focus on Modafinil, assuming that both Modafinil and Armodafinil are similarly compelling for excessive sleepiness treatment.

Modafinil in treating narcolepsy

Modafinil(Modalert, Modiodal, Modapro, Provigil) works on numerous brain advances at the similar time in order to create the pined stimulation. Narcolepsystudy.com researchers said the Modafinil pill affects the gamma-Aminobutyric acid, Histamine, Noradrenaline and Glutamate neurotransmitters as well as the Hypocretin (neuropeptide orexin). Thereby it produces a natural sense of being asleep and alert. In this way, Modafinil medicine treated the excessive sleepiness disorder. Another beneficial effect incorporated raised motivation which makes to increase the productivity and enhanced capacity to focus on work for a longer time.

By taking the Modafinil medicine, the patient stays awake for more than 8 hours by that it is convenient for them to take the pill in the morning. Some people find that it subside in the early afternoon and may choose to consume half of the prescribed dosage in the morning and the other half dose after lunch. In addition, Modafinil produces lesser side effects than the few another wake-alertness pill, yet it can cause nausea, headache, and insomnia. Rarely, it can produce an extreme and risky rash that warrants prompt medical consideration. Modafinil likewise influences birth control medications much less effectiveness, so women taking Modafinil should utilize a substitute method for birth control.

How modafinil works for treating hypersomnia?

Modafinil deals on the brain and produces a feeling of alertness by decreasing increasing the levels of dopamine in the brain. Scientists conducted a research on hypersomnia and said that it is one of the best medications to treat hypersomnia in 1988. It has proved, this medicine has worked effectively for the treatment of hypersomnia but it gives to the users less side effects. If you think you suffer from this disorder, do visit your physician as they will suggest you the right dosage of Modafinil. Taking treatment under doctor guidelines, you may not be suffered from any side effects moreover the medicine works effectively in your system.

Adderall

AdderallAdderall belongs to prescription-only drug and it is used for ADHD(anti-anxiety hyperactive disorder) and narcolepsy. People who have taken Adderall at unprescribed dosages are at a high exposure of enhancing addicted thereby they can not able to function normally without the medicine. So it is always better to take the weight pill under doctor guidelines so we can avoid the addiction problem.

 Adderall for narcolepsy and its effectiveness

Adderall contains a mixture of amphetamine and dextroamphetamine. These two mixtures are the central nervous system stimulants which affect the brain chemicals, which is unbalanced and control the hyperactivity. Since Adderall is effectively working for ADHD and Narcolepsy.

As narcolepsystudy.com suggest you follow the guidelines, which makes Adderall medication to be work effectively in your body.

  • Take Adderall for hypersomnia in the morning time
  • Start with lower dosage as prescribed by your physician. Do not increase the dose without getting the consultation from your doctor
  • Take this medicine with or without food
  • If you find any severe symptoms like chest pain, psychotic symptoms, change in skin color, rashes on toes or fingers, then consult your physician immediately
  • Avoid driving and machine operating work while taking the pill
  • Don’t stop taking the drug without consulting your doctor as this will lead to withdrawal symptoms
  • The pill started to work effectively within 3 hours after consumption

Why has Adderall preferred for Narcolepsy and ADHD related ailments?

The effectiveness of Adderall is considered to be preferred for narcolepsy and ADHD related disorder. The mixture of four varied amphetamine salts which mingles to provide one pill, Adderall, which makes the person stay awake since it is considered as short-acting forms. Most of the people who consumed Adderall medication for excessive sleepiness and ADHD associated problems stated that they are experienced lesser side effects. Moreover, the price of Adderall is very less compared to other sleep disorder medication cost by that many people preferred this pill for narcolepsy and ADHD disorders. Mostly, lower dose medication has been prescribed by a doctor for this kind of problems since it works potentially in the brain and helps to stay asleep and get relief from the hyperactive ailment.